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Unravelling the cellular effects of smoking is complicated because many effects manifest themselves only after prolonged low-grade exposure and are challenging to replicate experimentally

But as always, the fine print contains more useful information

(Although ITC has one ENDS product, Eon, its shortcomings and lack of popularity mean the company has no significant foothold in this space.) Little forward movement on promoting lower-risk alternatives to curb tobacco use is possible until the state can be separated from tobacco commerce

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Where there is no recognised alternative, animal testing may be necessary to meet safety, legal and / or regulatory requirements

The study adheres to standard principles of research integrity and proper source attribution